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Biographical Sketch
Dr. Montes is a biologist, applied physicist,
biophysicist/molecular biologist, and has received postdoctoral training
in pharmacology and toxicology. He received his B.A. in Biological
Sciences from the University of New Orleans after almost completing
a B.S. degree in Economics. He was engaged in biological research even
as a freshman in college, and managed the Plant Physiology Laboratory
at that school before receiving his B.A. Shortly afterwards, he obtained
an M.S. in Applied Physics from the same university. He received his
Ph.D. in Biophysics/Molecular Biology from the Pennsylvania State University,
where his major research interests were in virology and mutagenesis.
While working at Penn State he was the first researcher to successfully
infect mouse cells with HSV-1 as part of an effort to explain a phenomenon
called host-cell reactivation. Subsequently he obtained Postdoctoral
Training in Pharmacology/Toxicology at the Medical College of Virginia
(MCV) under an NIH training grant. At MCV he researched tumor promoters
and the possible effects of microwaves on carcinogenesis, using the
activation of sea urchin eggs as a tool; the results were negative.
As Research Assistant Professor in the Biophysics Department of the
University of Maryland School of Medicine he invented a novel way to
measure transmembrane fluxes, in which he used mass spectrometry and
stable isotopes, and he received substantial NSF and NIH funding as
a result of his work. Later, he worked in the Department of Pharmacology
and Experimental Therapeutics of the same university as Research Assistant
Professor, where he co-wrote two book chapters as principal author
on the subject matter of nicotinic acetylcholine receptors and patch-clamp
technique. While there, he coauthored a monograph for the U.S. Army
on the toxicology of organophosphates and other nerve agents.
Dr. Montes worked for awhile for a major defense contractor, SAIC
(Science Applications International Corporation), as a reviewer of
pharmacology and physiology grant proposals submitted to the Department
of Defense. Throughout his career, he has taught many college-level
courses, covering the areas of Chemistry, Geology, Astronomy, Physics,
Mathematics, Engineering, Biophysics, and, of course, Biology. After
eleven years of only teaching, Dr. Montes has returned to research
(see Research Interests below). He has a published patent pending (U.S.
Patent Publication Number: US-2004-0234620-A1) on a novel treatment
for herpetic lesions. |
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Selected Publications
Journal Articles
Nicotinic Responses in Acutely Dissociated Rat Hippocampal Neurons
and the Selective Blockade of Fast-Desensitizing Nicotinic Currents
by Lead. 1995. Ishihara, K., Alkondon, M., Montes, J.G., and E. X.
Albuquerque. J. Pharm. Exp. Ther. 273: 1471-1482..
Ontogenically-Related Properties of N-Methyl-D-Aspartate Receptors
in Rat Hippocampal Neurons and the Age-Specific Sensitivity of Developing
Neurons to Lead. 1995. Ishihara, K., Alkondon, M., Montes, J.G., and
Albuquerque, E.X. J. Pharm. Exp. Ther. 273 : 1459-1470.
Determination of Electric Field Threshold for Electrofusion of Erythrocyte
Ghosts: Comparison of "Pulse-First" and "Contact-First" Protocols.
1992. Wu, Y., Montes, J.G., and R.A. Sjodin. Biophysical J. 61:810-815.
Cell Density Dependence of UV Light Enhanced Reactivation of Herpes
simplex Type I and the Large Plaque Effect in C3H/10T½ Mouse
Fibroblasts. 1992. Montes, J. G. and W. D. Taylor. Photochem. Photobiol. 55:213-219.
Direct Inhibitory Action of EGTA-Ca Complex on Reverse-Mode Na/Ca
Exchange in Myxicola Giant Axons. 1990. Sjodin, R. A., Mahmoud, A.A.,
and J. G. Montes. J. Membr. Biol. 114:225‑230.
Regulation of Potassium and Magnesium Effluxes by External Magnesium
in Barnacle Muscle Fibres. 1990. Montes, J.G., Sjodin, R.A., Wu, Y.,
Chen, J-S, Yergey, A.L., and N. E. Vieira. Magnesium Research 34:239-248.
Anomalous Influence of Reduced Internal ATP Levels on Sodium Efflux
in Myxicola Giant Axons. 1989. Sjodin, R. A., Ortiz, O.E., and J. G.
Montes. J. Membr. Biology 108:61-71.
Simultaneous Bidirectional Magnesium Ion Flux Measurements in Single
Barnacle Muscle Cells by Mass Spectrometry. 1989. Montes, J. G., Sjodin,
R.A., Yergey, A.L., and N. E. Vieira. Biophysical J. 56:437-446.
The Effects of Ultraviolet Light on Host Cell Reactivation and Plaque
Size of Herpes simplex Virus Type I in C3H/10T1/2 Mouse Cells.
1986. Montes, J. G., and W. D. Taylor. Photochem. Photobiol. 43:35-40.
Further Evidence That Ultraviolet Light Enhanced Reactivation of
Simian Virus 40 in Monkey Kidney Cells Is Not Accompanied by Mutagenesis.
1982. Taylor, W. D., Bockstahler, L.E., Montes, J., Babich, M.A., and
C. D. Lytle. Mutation Research, 105:291-298.
Book Chapters
Electrophysiological Methods for the Study of Neuronal Nicotinic
Receptor Ion Channels. 1994. Montes, J.G., Alkondon, M., Pereira, E.F.R.,
Castro, N., and Albuquerque, E.X. In "Ion Channels in Excitable
Membranes" (Narahashi, T. ed.), Methods in Neurosci.19,
pp. 121-146, Academic Press, San Diego, CA.
Nicotinic Acetylcholine Receptor of the Mammalian Central Nervous
System. 1994. Montes, J.G., Alkondon, M., Pereira, E.F.R., and Albuquerque,
E.X. In "Handbook of Membrane Channels" (Perrachia,
C., ed.), pp. 269-285, Academic Press, San Diego, CA.
Monographs and Books
"The Direct Actions of Organophosphates, Carbamates, and Oximes
on Nicotinic Acetylcholine Receptors". Albuquerque, E.X., Swanson,
K., Montes, J.G., and Y. Aracava. Submitted to the United States Army
Medical Research Institute of Chemical Defense. 1994. |
Dr. Joseph Montes