Research Interest

Determining whether marijuana, during early postnatal development, affects the activity of peripheral arterial chemoreceptors, which modulate respiratory responses to hypoxia and the level of arousal during sleep , using in situ hybridization histochemistry to characterize the pattern and level of mRNA expression of the cannabinoid 1 type receptor (CB1R), and immunohistochemistry, light, confocal and electron microscopy to characterize the pattern of CB1R protein expression in the carotid body, superior cervical ganglia (SCG) and nodose-petrosal-jugular ganglia (NG-PG-JG) complex in newborn rats.

Publications

1. Jett DA, Beckles RA, Navoa RV, MCLEMORE GL.  Expression of brain nicotinic receptor subtypes in rats exposed to lead during development. Neurotoxicology (submitted, 2001).
2. Jett, D.A., Navoa, R., MCLEMORE, G.L. Cognitive Function and cholinergic neurochemistry in juvenile rats exposed to low-levels of chlorpyrifos during development. Toxicological Sci. (submitted, 2000).
3. Sañudo-Peña MC, Force M, Tsou K, MCLEMORE GL, Roberts L, Walker JM. The dopaminergic system does not play a major role in the precipitated cannabinoid withdrawal syndrome. Acta Pharmacologica Sinica. 20(12): 1121-1124, 1999.
4.  MCLEMORE G.L., Kest B, Inturrisi CE. Effects of excitatory amino acid receptor antagonists on morphine dependence. Brain Res. 778: 120-126, 1997.
5. Kest, B., MCLEMORE GL, Kao B, Inturrisi CE. The competitive alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor antagonist, LY293558, attenuates and reverses analgesic tolerance to morphine but not to delta or kappa opioids. J. Pharmacol. Exp. Ther. 283:1249-1255, 1997.

Courses

Honors Intorductory Biology 111 [PDF Syllabus] [Words of Wisdom]